Assembly system of direct modified superparamagnetic iron oxide nanoparticles for target-specific MRI contrast agents

作者：Tanaka Kazuo; Kitamura Narufumi; Morita Masahito; Inubushi Toshiro; Chujo Yoshiki^*

来源：Bioorganic & Medicinal Chemistry Letters, 2008, 18(20): 5463-5465.

DOI：10.1016/j.bmcl.2008.09.035

• MRI
• contrast agent
• SPIO
• nanoparticle
• aptamer
• assembly

We report the direct modification of SPIOs with a biomolecule and the target-specific assembly system of these modified SPIOs for using MRI contrast agents. The transverse relaxation rate of the aqueous solutions containing the modified SPIOs was altered by the dispersion state.

• 出版日期2008-10-15