F-18-FLT PET/CT imaging in a Wister rabbit inflammation model

作者：Tan, Yeying; Liang, Jun; Liu, Defeng; Zhu, Feng; Wang, Guanmin; Ding, Xuemei; Han, Conghui^*

来源：Experimental and Therapeutic Medicine, 2014, 8(1): 69-72.

DOI：10.3892/etm.2014.1687

• 3 '-deoxy-3 '-F-18-fluorothymidine
• Staphylococcus aureus model
• gentamicin plus calcium sulphate model

The aim of the present study was to determine the tumour specificity of the newly developed nucleoside metabolic positron emission tomography (PET) tracer, 3'-deoxy-3'-F-18-fluorothymidine (F-18-FLT). Using F-18-FLT PET imaging, DNA synthesis and cell proliferation were detected in Staphylococcus aureus (S. aureus) abscess and calcium sulphate models in Wister rabbits. A total of eight rabbits were implanted with S. aureus in the left tibia to induce an inflammatory process. Calcium sulphate + gentamicin was implanted in the right tibia to induce a physical stimulus without bacterial multiplication. After four weeks, the animals underwent F-18-FLT PET imaging, bacterial culturing and tissue pathology. The uptake of F-18-FLT was significantly higher in the abscess site compared with that in the granuloma, with maximum standardised uptake values of 5.76 +/- 0.25 and 1.15 +/- 0.32, respectively (P<0.01). This indicates that F-18-FLT is not a specific tumour tracer since active inflammation also results in the uptake of this compound. However, the tumour specificity of this tracer is higher compared with that of F-18-fluorodeoxyglucose. Therefore, F-18-FLT may be useful in the differential diagnosis of benign and malignant tumours.

• 出版日期2014-7
• 单位徐州医科大学