Lymphoepithelioma-like gastric carcinoma: an unusual consequence of Epstein-Barr virus infection in an HIV-infected woman

作者：Paniz Mondolfi P^*; Pang Y; Cohen S; Balderacchi J; Tsveniashvili L; Polsky B; Sordillo E M

来源：International Journal of STD & AIDS, 2013, 24(1): 59-62.

DOI：10.1258/ijsa.2012.012131

• HIV
• AIDS
• malignancy
• Epstein-Barr virus
• EBV
• lymphoepithelionna-like gastric carcinoma

Lymphoepithelioma-like-gastric carcinoma (LEL-GC) is an Epstein-Barr virus (EBV)-associated neoplasm of the stomach reported to have a better prognosis than conventional gastric adenocarcinoma. Unlike other EBV-associated malignancies, particularly lymphoproliferative disorders and undifferentiated nasopharyngeal carcinoma, for which risk has been shown to increase in human immunodeficiency virus (HIV) infection, LEL-GC remains rare; only one HIV-infected patient with LEL-GC has been reported previously. We describe an aggressive case of EBV-associated LEL-GC in a woman co-infected with HIV 1 and hepatitis C virus. In situ hybridization of an endoscopic biopsy specimen for EBV-encoded small RNA confirmed the presence of this agent exclusively in the gastric cancer cells. Our patient had recently started antiretroviral therapy, suggesting that immune reconstitution may have been a factor in presentation of this tumour.

• 出版日期2013-1