Downregulation of microRNA-155 ameliorates high glucose-induced endothelial injury by inhibiting NF-kappa B activation and promoting HO-1 and NO production

作者：Zhang Xi; Liu Xiangyang; Li Yang; Lai Jingbo; Zhang Nana; Ming Jie; Ma Xianjie; Ji Qiuhe; Xing Ying

来源：Biomedicine & Pharmacotherapy, 2017, 88: 1227-1234.

DOI：10.1016/j.biopha.2017.01.122

• Endothelial dysfunction
• miR-155
• ROS/NF-κB signaling
• Nrf2/HO-1 signaling
• eNOS/NO production

Background
High glucose-associated endothelial cell injury plays an important role in the pathogenesis of diabetic vascular complications. This study was undertaken to explore the role of miR-155 in high glucose-induced endothelial dysfunction and the underlying molecular mechanisms.

• 出版日期2017-4