Drinking water arsenic exposure and blood pressure in healthy women of reproductive age in Inner Mongolia, China

作者：Kwok Richard K; Mendola Pauline; Liu Zhi Yi; Savitz David A; Heiss Gerardo; Ling He Ling; Xia Yajuan; Lobdell Danelle; Zeng Donglin; Thorp John M Jr; Creason John P; Mumford Judy L

来源：Toxicology and Applied Pharmacology, 2007, 222(3): 337-343.

DOI：10.1016/j.taap.2007.04.003

• arsenic
• drinking water
• blood pressure
• cardiovascular disease
• post-natal
• reproductive health
• women
• Inner Mongolia, China

The extremely high exposure levels evaluated in prior investigations relating elevated levels of drinking water arsenic and hypertension prevalence make extrapolation to potential vascular effects at lower exposure levels very difficult. A cross-sectional study was conducted on 8790 women who had recently been pregnant in an area of Inner Mongolia, China known to have a gradient of drinking water arsenic exposure. This study observed increased systolic blood pressure levels with increasing drinking water arsenic, at lower exposure levels than previously reported in the literature. As compared to the referent category (below limit of detection to 20 mu g of As/L), the overall population mean systolic blood pressure rose 1.29 mm Hg (95% CI 0.82, 1.75), 1.28 mm Hg (95% CI 0.49, 2.07), and 2.22 mm Fig (95% Cl 1.46, 2.97) as drinking water arsenic concentration increased from 21 to 50, 51 to 100, and > 100 mu g of As/L, respectively. Controlling for age and body weight (n = 3260), the population mean systolic blood pressure rose 1.88 mm Hg (95% CI 1.03, 2.73), 3.90 mm Hg (95% CI 2.52, 5.29), and 6.83 mm Fig (95% CI 5.39, 8.27) as drinking water arsenic concentration increased, respectively. For diastolic blood pressure effect, while statistically significant, was not as pronounced as systolic blood pressure. Mean diastolic blood pressure rose 0.78 mm Hg (95% Cl 0.39, 1.16), 1.57 mm Hg (95% CI 0.91, 2.22) and 1.32 mm Hg (95% Cl 0.70, 1.95), respectively, for the overall population and rose 2.11 mm Fig (95% CI 1.38, 2.84), 2.74 mm Hg (95% CI 1.55, 3.93), and 3.08 mm Hg (95% CI 1.84, 4.31), respectively, for the adjusted population (n=3260) at drinking water arsenic concentrations of 21 to 50, 51 to 100, and > 100 mu g of As/L. If our study results are confirmed in other populations, the potential burden of cardiovascular disease attributable to drinking water arsenic is significant.

• 出版日期2007-8-1
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