Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (+/-)-anatoxin A poisoning

作者：Banerjee Subham; Chattopadhyay Pronobesh^*; Ghosh Animesh; Bhattacharya Shiv Sankar; Kundu Amit; Veer Vijay

来源：Journal of Food and Drug Analysis, 2014, 22(2): 264-270.

DOI：10.1016/j.jfda.2014.01.022

• Eserine
• International Conference on Harmonisation guidelines
• Pralidoxime chloride
• Stability
• Transdermal patch

The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (+/-)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

• 出版日期2014-6