Fe3O4-ZIF-8 assemblies as pH and glutathione responsive T2-T1 switching magnetic resonance imaging contrast agent for sensitive tumor imaging in vivo

作者：Lin, Jiaomin; Xin, Pengyan; An, Lu; Xu, Yanjun; Tao, Cheng; Tian, Qiwei; Zhou, Zhiguo; Hu, Bing^*; Yang, Shiping^*

来源：Chemical communications, 2019, 55(4): 478-481.

DOI：10.1039/c8cc08943d

• IRON-OXIDE NANOPARTICLES
• METAL-ORGANIC FRAMEWORKS
• ONE-POT SYNTHESIS
• DESIGN
• TARGET

A small Fe3O4 nanoparticles-based T-1 contrast agent was assembled into a pH- and glutathione-responsive T-2-T-1 switching contrast agent, Fe3O4-ZIF-8. In vivo T-1-weighted images of mice showed that Fe3O4-ZIF-8 displayed darkening contrast enhancement for liver sites, while darkening to brightening contrast enhancement at tumor sites, giving large inverse contrast for distinguishing the normal and tumor tissues.

• 出版日期2019-1-14
• 单位上海交通大学; 上海师范大学