AN EX VIVO HUMAN LUNG MODEL FOR ULTRASOUND-GUIDED HIGH-INTENSITY FOCUSED ULTRASOUND THERAPY USING LUNG FLOODING

作者：Wolfram Frank^*; Reichenbach Juergen R; Lesser Thomas G

来源：Ultrasound in Medicine and Biology, 2014, 40(3): 496-503.

DOI：10.1016/j.ultrasmedbio.2013.11.007

• Lung flooding
• Lung sonography
• Non-small cell lung cancer
• Acoustic properties
• High-intensity
• focused ultrasound

The usability of an ex vivo human lung model for ablation of lung cancer tissue with high-intensity focused ultrasound (HIFU) is described. Lung lobes were flooded with saline, with no gas remaining after complete atelectasis. The tumor was delineated sono-morphologically. Speed of sound, tissue density and ultrasound attenuation were measured for flooded lung and different pulmonary cancer tissues. The acoustic impedance of lung cancer tissue (1.6-1.9 mega-Rayleighs) was higher than that of water, as was its attenuation coefficient (0.31-0.44 dB/cm/MHz) compared with that of the flooded lung (0.12 dB/cm/MHz). After application of HIFU, the temperature in centrally located lung cancer surrounded by the flooded lung increased as high as 80 degrees C, which is sufficient for treatment. On the basis of these preliminary results, ultrasound-guided HIFU ablation of lung cancer, by lung flooding with saline, appears feasible and should be explored in future clinical studies.

• 出版日期2014-3