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摘要
Measurement of areal bone mineral density (aBMD) by dual-energy x-ray absorptiometry (DXA) has been shown to predict fracture risk High-resolution peripheral quantitative computed tomography (HR-pQCT) yields additional information about volumetric BMD (vBMD), microarchitecture, and strength that may increase understanding of fracture susceptibility Women with (n=68) and without (n=101) a history of postmenopausal fragility fracture had aBMD measured by DXA and trabecular and cortical vBMD and trabecular microarchitecture of the radius and tibia measured by HR-pQCT Finite-element analysis (FEA) of HR-pQCT scans was performed to estimate bone stiffness DXA T-scores were similar in women with and without fracture at the spine, hip, and one-third radius but lower in patients with fracture at the ultradistal radius (p < 01) At the radius fracture, patients had lower total density, cortical thickness, trabecular density, number, thickness, higher trabecular separation and network heterogeneity (p < 0001 to 04) At the tibia, total, cortical, and trabecular density and cortical and trabecular thickness were lower in fracture patients (p < 0001 to 03) The differences between groups were greater at the radius than at the tibia for inner trabecular density, number, trabecular separation, and network heterogeneity (p < 01 to 05) Stiffness was reduced in fracture patients, more markedly at the radius (41% to 44%) than at the tibia (15% to 20%) Women with fractures had reduced vBMD, microarchitectural deterioration, and decreased strength These differences were more prominent at the radius than at the tibia HR-pQCT and FEA measurements of peripheral sites a
- 出版日期2010-12
