Noninvasive ventilation: Efficacy of a new ventilatory mode in patients with obesity-hypoventilation syndrome

作者：Couillard A^*; Pepin J L; Rabec C; Cuvelier A; Portmann A; Muir J F

来源：Revue des Maladies Respiratoires, 2015, 32(3): 283-290.

DOI：10.1016/j.rmr.2014.02.013

• Obesity-hypoventilation syndrome
• Noninvasive ventilation
• Sleep
• Quality of life
• Physical activity

Noninvasive ventilation is recommended to correct the nocturnal hypoventilation and relieve the symptoms of patients with the obesity-hypoventilation syndrome (OHS). The benefits of fixed pressure ventilation (S/T technology) are recognized but limited on account of the variability of nocturnal ventilatory requirements. The new technique AVAPS-AE (automatic EPAP) allows adjustment of the pressure according to the volume currently targeted. Its efficacy has not yet been evaluated. Our objectives are to evaluate firstly, whether AVAPS-AE optimizes the benefits of S/T technology on sleep architecture and quality, secondly, whether these benefits are associated with an improvement in gas exchange, symptoms, exercise tolerance, level of physical activity and quality of life of patients with OHS. In this multicenter trial, 60 newly diagnosed patients with OHS will be randomized to the control (SIT) and trial (AVAPS-AE) groups. A standardized titration procedure will be followed for the calibration of the ventilators. Functional evaluations (polysomnography, blood gases, impedance measurements and walking tests), questionnaires (physical activity, quality of life, quality of sleep and daytime somnolence) visual scales (fatigue, headaches) and a recording of activity will be undertaken after two months of ventilation.

• 出版日期2015-3