Determination of Phenacetin and Bupropion in Rat Plasma After Acute Hydrogen Sulfide Poisoning

作者：Yang Xuezhi; Zhang Zhennan; Lin Dan; Wang Xianqin; Lin Guanyang^*

来源：Latin American Journal of Pharmacy, 2014, 33(4): 691-695.

• Acute hydrogen sulfide poisoning
• Bupropion
• Pharmacokinetic
• Phenacetin

Hydrogen sulfide (H2S) is one of the neurotoxic gases with suffocating and irritating. Its main target organs of toxic effects are the central nervous system and respiratory system. The experimental rats were randomly divided into three groups, a control group (0 ppm) and two acute hydrogen sulfide poisoning groups (100 and 200 ppm). The concentrations of phenacetin and bupropion in plasma were measured by using gradient elution LC-MS. The results of pharmacokinetic study of the acute hydrogen sulfide poisoning and control groupa after intravenous administration showed that the AUC((0-infinity)) and C-max for phenacetin and bupropion had a statistically significant, and that AUC((0-infinity)) and C-max decrease when increasing the concentration of hydrogen sulfide poisoning.

• 出版日期2014
• 单位温州医科大学