Comparison of pulsed photothermal radiometry, optical coherence tomography and ultrasound for melanoma thickness measurement in PDMS tissue phantoms

作者：Wang Tianyi^*; Mallidi Srivalleesha; Qiu Jinze; Ma Li L; Paranjape Amit S; Sun Jingjing; Kuranov Roman V; Johnston Keith P; Milner Thomas E

来源：Journal of Biophotonics, 2011, 4(5): 335-344.

DOI：10.1002/jbio.201000078

• malignant melanoma
• PDMS tissue phantom
• pulsed photothermal radiometry
• optical coherence tomography
• ultrasound
• Monte Carlo simulation
• three-dimensional heat transfer model

Melanoma accounts for 75% of all skin cancer deaths. Pulsed photothermal radiometry (PPTR), optical coherence tomography (OCT) and ultrasound (US) are non-invasive imaging techniques that may be used to measure melanoma thickness, thus, determining surgical margins. We constructed a series of PDMS tissue phantoms simulating melanomas of different thicknesses. PPTR, OCT and US measurements were recorded from PDMS tissue phantoms and results were compared in terms of axial imaging range, axial resolution and imaging time. A Monte Carlo simulation and three-dimensional heat transfer model was constructed to simulate PPTR measurement. Experimental results show that PPTR and US can provide a wide axial imaging range (75 mu m-1.7 mm and 120-910 mu m respectively) but poor axial resolution (75 and 120 mu m respectively) in PDMS tissue phantoms, while OCT has the most superficial axial imaging range (14-450 mu m) but highest axial resolution (14 mu m). The Monte Carlo simulation and three-dimensional heat transfer model give good agreement with PPTR measurement. PPTR and US are suited to measure thicker melanoma lesions (> 400 mu m), while OCT is better to measure thin melanoma lesions (< 400 mu m).

• 出版日期2011-5