alpha-glucosidase inhibitory activities of myricetin in animal models of diabetes mellitus

作者：Kang Soo Jeong; Park Jung Han Yoon; Choi Ha Neul; Kim Jung In^*

来源：Food Science and Biotechnology, 2015, 24(5): 1897-1900.

DOI：10.1007/s10068-015-0249-y

• myricetin
• alpha-glucosidase
• glucose
• glycated hemoglobin
• db/db mouse

The alpha-glucosidase inhibitory activity of myricetin in vivo was investigated. Streptozotocininduced diabetic rats were administered a starch solution (1 g/kg) with and without myricetin (100 mg/kg) or acarbose (40 mg/kg) after an overnight fast. Myricetin and acarbose alleviated postprandial hyperglycemia conditions, compared with untreated rats. Consumption of 0.08% myricetin or 0.03% acarbose in the diet for 7 weeks significantly (p < 0.05) reduced the serum fasting glucose, blood glycated hemoglobin, and maltase activities of the small intestine in db/db mice, compared with controls. Myricetin can be beneficial for control of hyperglycemia in diabetes mellitus partly via inhibition of the a-glucosidase activity.

• 出版日期2015-10