ADRA2A polymorphisms and ADHD in adults: Possible mediating effect of personality

作者：Silva de Cerqueira Caio Cesar; Polina Evelise Regina; Contini Veronica; Coelho Marques Francine Zanquetta; Grevet Eugenio Horacio; Iglesias Salgado Carlos Alberto; Guimaraes da Silva Paula Oliveira; Picon Felipe Almeida; Belmonte de Abreu Paulo; Dotto Bau Claiton Henrique

来源：Psychiatry Research, 2011, 186(2-3): 345-350.

DOI：10.1016/j.psychres.2010.08.032

• Harm avoidance
• Heterogeneity
• Novelty seeking
• Persistence
• Temperament profiles

Several studies have tested for the association between polymorphisms in the ADRA2A gene and childhood ADHD. A meta-analysis of these results, however, has pointed towards a significant heterogeneity, raising the need for explanatory studies. As the effect of other relevant clinical characteristics could be a possible source, we studied three polymorphisms in the ADRA2A gene (-1291 C>G-Mspl or rs1800544; 262 G>A-Hhal or rs1800544; 1780 C>T-Dral or rs553668) in 403 adult patients with ADHD assessed in relation to comorbidity and personality characteristics, as well as in 232 controls. The diagnosis followed DSM-IV criteria, and personality dimensions were evaluated with the Temperament and Character Inventory (TCI). There were no significant differences in allele and genotype frequencies between cases and controls. Patients carrying the G allele of rs1800544 presented lower scores in harm avoidance, and carriers of the T allele of rs553668 had more novelty seeking and less harm avoidance and persistence. Additionally, the haplotype carrying the G-G-T alleles (rs1800544-rs1800545-rs553668) was associated with lower scores in harm avoidance and persistence, and higher scores in novelty seeking compared to other haplotypes. These findings suggest that the conflicting findings obtained in association studies between ADRA2A polymorphisms and ADHD might be related to temperament profiles, and support additional studies addressing these effects in larger samples.

• 出版日期2011-4-30