Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation

作者：Ramos P M; Brianezi G; Martins A C P; da Silva M G; Marques M E A; Miot H A^*

来源：International Journal of Cosmetic Science, 2016, 38(6): 651-654.

DOI：10.1111/ics.12341

• alopecia
• androgenic alopecia
• apoptosis
• hair growth
• inflammation

ObjectiveThe objective of this study is to evaluate apoptosis in hair follicles of patients with female pattern hair loss (FPHL) and its association with follicular microinflammation.
MethodCross-sectional study involving 17 women with FPHL and five controls. Scalp skin samples were processed for HE and TUNEL assays. The variables were compared according to the categories of follicles (terminal versus miniaturized) and groups of patients (FPHL vs. controls).
ResultsThere was a higher apoptosis index among miniaturized follicles and among the test cases (P < 0.01). Microinflammation was prominent among miniaturized follicles, especially from FPHL (P = 0.02). In addition, a positive correlation between inflammatory infiltrate and apoptosis in miniaturized follicles (r(S) = 0.68; P < 0.01) was found.
ConclusionsApoptosis was prominent in hair follicles from the FPHL group, as well as in miniaturized ones. Moreover, it was also correlated with the inflammatory infiltrate, which suggests that inflammation can lead to apoptosis and play a role in the pathogenesis of follicle miniaturization.
Resume
ObjectifEvaluer l'apoptose dans les follicules pileux de patients avec perte de cheveux chez les femmes (FPHL) et son association a une micro-inflammation folliculaire.
MethodeEtude transversale impliquant 17 femmes avec FPHL et cinq temoins. Des echantillons de peau du cuir chevelu ont ete traites pour des essais HE et TUNEL. Les variables ont ete comparees en fonction des categories de follicules (terminaux vs. miniaturises) et des groupes de patients (FPHL vs. temoins).
ResultatsIl y avait un indice d'apoptose plus eleve chez les follicules miniaturises et parmi les cas du test (P < 0.01). La micro-inflammation etait importante parmi les follicules miniaturises, en particulier dans le cas FPHL (P = 0.02). En outre, une correlation positive entre l'infiltrat inflammatoire et l'apoptose dans les follicules miniaturises (rS = 0.68; P < 0.01) a ete trouvee.
ConclusionsL'apoptose est importante dans les follicules pileux du groupe FPHL, ainsi que dans les follicules miniaturises. Par ailleurs, elle a egalement ete trouvee correlee a l'infiltrat inflammatoire, ce qui suggere que l'inflammation peut conduire a l'apoptose et jouer un role dans la pathogenese de la miniaturisation du follicule.

• 出版日期2016-12