Asymmetric Catalysis in the Synthesis of Azaflavanones

作者:Pinheiro Sergio; Muri Estela M F*; de Oliveira Rafael P R F; Dias Luiza R S; Greco Sandro J
来源:Mini-Reviews in Organic Chemistry, 2017, 14(5): 400-406.
DOI:10.2174/1570193X14666170518120501

摘要

Azaflavanones are synthetic aza-analogues of flavanones possessing several biological interests, especially as anticancer. Since individual enantiomers of azaflavanones showed different anticancer activities, the development of asymmetric routes to access this class of compounds has appeared in the literature. This review shows the different approaches for the enantioselective synthesis of azaflavanones based on asymmetric catalysis.

  • 出版日期2017