Amyloid precursor protein and growth-associated protein 43 expression in brain white matter and spinal cord tissues in a rat model of experimental autoimmune encephalomyelitis

作者：Wang, Yizhou; Kou, Shuang; Tang, Jingcheng; Zhang, Ping; Zhang, Qiuxia; Liu, Yan; Zheng, Qi; Zhao, Hui; Wang, Lei^*

来源：Neural Regeneration Research, 2011, 6(2): 101-106.

DOI：10.3969/j.issn.1673-5374.2011.02.004

• amyloid precursor protein
• axonal regeneration
• central nervous system
• experimental autoimmune encephalomyelitis
• growth-associated protein 43

Studies have demonstrated that amyloid precursor protein (APP) expression increases in multiple sclerosis tissues during acutely and chronically active stages. To determine the relationship between axonal injury and regeneration in multiple sclerosis, an animal model of experimental autoimmune encephalomyelitis was induced using different doses of myelin basic protein peptide. APP and growth-associated protein 43 (GAP-43), which is considered a specific marker of neural regeneration, were assessed by western blot analysis. Expression of APP and GAP-43, as well as the correlation between these two proteins, in brain white matter and spinal cord tissues of experimental autoinnmune encephalomyelitis rats at different pathological stages was analyzed. Results showed that APP and GAP-43 expression increased during the acute stage and decreased during remission, with a positive correlation between APP and GAP-43 expression in brain white matter and spinal cord tissues. These results suggest that APP and GAP-43 could provide nutritional and protective effects on damaged neurons.

• 出版日期2011-1-15
• 单位首都医科大学; 中国中医科学院望京医院