Disruption of zinc and copper interactions with A beta(1-40) by a non-toxic, isoniazid-derived, hydrazone: a novel biometal homeostasis restoring agent in Alzheimer's disease therapy?

作者：Hauser Davis R A; de Freitas L V; Cukierman D S; Cruz W S; Miotto M C; Landeira Fernandez J; Valiente Gabioud A A; Fernandez C O; Rey N A^*

来源：Metallomics, 2015, 7(5): 743-747.

DOI：10.1039/c5mt00003c

Disruptions of biometal-A beta(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg(-1), showing potential as an anti-Alzheimer's drug.

• 出版日期2015