Analysis of amino acid changes in NS protein of influenza A/(H3N2) virus in Iranian isolates

作者：Rogo Lawal Dahiru; Rezaei Farhad^*; Shafiei Jandaghi Nazanin Z; Ghavami Nastaran; Fatemi Nasab Ghazal; Mokhtari Azad Talat

来源：Future Virology, 2015, 10(11): 1195-1206.

DOI：10.2217/fvl.15.90

• influenza A (H3N2) virus
• Iran
• mutation
• NS gene

Aim: Roles of NS gene of influenza A virus in virulence and replication are well established but extent of its variation in seasonal influenza A (H3N2) viruses in Iran is not well known. Materials & methods: NS gene of 37 (A/H3N2) virus isolates were sequenced and analyzed for information on genetic changes. Results: Data analysis of NS1 protein revealed two amino acid substitutions E26K and Q193R in almost all strains. Substitutions in T58P in 27.0%, A86S in 13.5% and each of V11G, M81I and P85T in 2.7% Iranian strains were also observed. Mutations in NS2/NEP protein were observed in K36E, Q101L and F107S. Conclusion: Many mutations were observed for the first time in Iranian strains. Their function remains to be determined.

• 出版日期2015