科研之友
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摘要
To study the anti-bacterial constituents from endophytic fungus 093701 of mangrove plant Cerbera manghas, three compounds were isolated by column chromatography from the broth of endophytic fungus Penicillium sp. of Mangrove plant Cerbera manghas, and their structures were elucidated as 4-(3-hydroxybutan-2-yl)-3,6- dimethylbenzene-1,2-diol(1), 4-(3-hydroxybutan-2-yl)-3-acetyl-6-methylbenzene-1,2-diol(2), 3,4,5-trimethyl-1,2-benzenediol(3) by MS, NMR, H-1-H-1 COSY, HMQC, HMBC etc.. Among them, compounds 1 and 2 were new compounds, compound 3 was a new natural product. Bioassay results showed that compounds 1 and 3 possessed inhibitory effects on MRSA, while compound 2 had no anti-MRSA activity.
