科研之友
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摘要
A rapid system for the sensitive non-contact detection of proteins using actuated magnetic particle labels, which are measured with a magneto-electric torque (MET) sensor, is described. The system contains MET sensor with the cantilever of magnet and the "test strip" of magnetic beads has been fabricated. The performance of MET sensor is demonstrated using magnetic beads and its detection limit was found to be 0.05 mg/mL. Furthermore, the biomarkers of alpha-fetoprotein is captured by immobilized anti-AFP antibodies on the surface of the "test strip" and detected using magnetic beads labeled with anti-AFP antibodies. The detection limit was found to be 100 ng/mL. The low sample volume, high analytical performance and high detecting speed coupled with the inexpensive, mass-producible, hand-held MET biosensor make the system especially suitable for sensitive testing outside of laboratory environments.
- 出版日期2018-12-10
- 单位中国科学院宁波材料技术与工程研究所; 中国科学院大学
