Anti-herpes virus activity of silibinin, the primary active component of Silybum marianum

作者：Cardile Anthony P^*; Mbuy Gustave K N

来源：Journal of Herbal Medicine, 2013, 3(4): 132-136.

DOI：10.1016/j.hermed.2013.07.002

• Silybum marianum
• Silibinin
• Silybin
• HSV-2
• HSV
• Herpes

Silibinin (silybin A and silybin B), the primary active component of Silybum marianum has antiviral activity against herpes simplex virus, type 2 (HSV-2). The fifty percent cytotoxic dose (CD50) of silibinin was 378 mu g/ml. By plaque reduction assay silibinin had a weak antiviral effect against HSV-2 with a fifty percent inhibitory concentration (IC50) of 100 mu g/ml and therapeutic index of 3.8. As a virucide, silibinin was more potent with an IC50 of 5 mu g/ml and therapeutic index of 76. Further investigations of the mechanisms of action of silibinin against herpes simplex viruses and subsequent silibinin monotherapy or combination therapy with other flavonoids as a topical treatment for genital herpes are warranted.

• 出版日期2013-12