A flexible pentacene thin film transistors as disposable DNA hybridization sensor

作者：Kim Jung Min; Jha Sandeep Kumar; Lee Dong Hoon; Chand Rohit; Jeun Jun Ho; Kim Yong Sang^*

来源：Journal of Industrial and Engineering Chemistry, 2012, 18(5): 1642-1646.

DOI：10.1016/j.jiec.2012.02.026

• Hybridization sensor
• Pentacene thin film transistor
• Disposable sensor
• Label-free

We fabricated a disposable DNA hybridization sensor using pentacene thin film transistors (TFTs) on flexible substrate. The analytes, 100-mer ss-DNA (poly A and poly T) or 100 bp ds-DNA were immobilized directly on the surface of the pentacene layer, thereby producing a dramatic change in the electrical properties of the devices. The electrical characteristics of devices were studied as a function of DNA immobilization conditions, DNA concentrations and between ss- and ds-DNA. Based on these results, we propose a disposable label-free sensor for DNA hybridization through direct measurement of electrical properties by the immobilization of DNA on flexible pentacene TFTs.

• 出版日期2012-9-25