Development and characterization of nanocapsules comprising dodecyltrimethylammonium chloride and kappa-carrageenan

作者：Rosas Durazo A; Lizardi J; Higuera Ciapara I; Arguelles Monal W; Goycoolea F M^*

来源：Colloids and Surfaces B: Biointerfaces , 2011, 86(1): 242-246.

DOI：10.1016/j.colsurfb.2011.03.020

• Dodecyltrimethylammonium chloride
• Carrageenan
• Nanocapsules

The aim of this work was to develop and characterize a new type of nanocapsules. To this end, a nanoemulsion bearing an oily core (Miglyol 812) was obtained by spontaneous emulsification and stabilized by dodecyl-trimethylammonium chloride (DTAC), a commercial cationic surfactant; this nanoemulsion was coated with proportionally very small amounts of kappa-carrageenan (at molar charge ratios of Z <= 0.0045) that interact predominantly by an electrostatic mechanism with the positively charged sites at the polar heads of DTAC at the nanoemulsion's surface to harness nanocapsules of average size similar to 250-330 nm and zeta potential (zeta) ranging from similar to+80 to +7 mV. The potential application of the new type of developed nanosystems as drug delivery vehicles has yet to be investigated and fully realized.

• 出版日期2011-8-1