A History of Drug-Induced Torsades de Pointes Is Associated With T-wave Morphological Abnormalities

作者：Bhuiyan Tanveer A.; Graff Claus; Kanters Jorgen K.; Melgaard Jacob; Toft Egon; Kaeaeb Stefan; Struijk Johannes J.^*

来源：Clinical Pharmacology & Therapeutics, 2018, 103(6): 1100-1106.

DOI：10.1002/cpt.886

The hypothesis of the study is that Torsades de pointes (TdP) history can be better identified using T-wave morphology compared to Fridericia-corrected QT interval (QTcF) at baseline. ECGs were recorded at baseline and during sotalol challenge in 20 patients with a history of TdP (+TdP) and 16 patients without previous TdP (-TdP). The QTcF and T-wave morphology combination score (MCS) were calculated. At baseline, there was no significant difference in QTcF between the groups (+TdP: QTcF = 446 +/- 9 ms; -TdP: QTcF = 431 +/- 9 ms, P = 0.27). In contrast, MCS was significantly different between the groups at baseline (+TdP: MCS = 1.07 +/- 0.095; -TdP: MCS = 0.74 +/- 0.07, P = 0.012). Both QTcF and MCS could be used to discriminate between +TdP and -TdP after sotalol but only MCS reached statistical significance at baseline. Combining QTcF with MCS provided a significantly larger difference between groups than QTcF alone.

• 出版日期2018-6