Systemic therapy in the management of metastatic or advanced salivary gland cancers

作者：Lagha Aymen^*; Chraiet Nesrine; Ayadi Mouna; Krimi Sarra; Allani Bassem; Rifi Hela; Raies Henda; Mezlini Amel

来源：Oral Oncology, 2012, 48(10): 948-957.

DOI：10.1016/j.oraloncology.2012.05.004

• Review
• Salivary glands
• Adenocystic
• Adenocarcinoma
• Mucoepidermoid
• Treatment
• Chemotherapy
• Targeted therapy
• Hormone therapy

Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers.

• 出版日期2012-10