Zika virus and neurologic autoimmunity: the putative role of gangliosides

作者：Anaya Juan Manuel^*; Ramirez Santana Carolina; Salgado Castaneda Ignacio; Chang Christopher; Ansari Aftab; Gershwin M Eric

来源：BMC Medicine, 2016, 14(1): 49.

DOI：10.1186/s12916-016-0601-y

• Autoimmunity
• Gangliosides
• Guillain-Barre syndrome
• Microcephaly
• Zika virus

An increasing number of severe neurological complications associated with Zika virus (ZIKV), chiefly Guillain-Barre syndrome (GBS) and primary microcephaly, have led the World Health Organization to declare a global health emergency. Molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of GBS preceded by infection, while a direct toxicity of ZIKV on neural cells has been raised as the main mechanism by which ZIKV induces microcephaly. Gangliosides are crucial in brain development, and their expression correlates with neurogenesis, synaptogenesis, synaptic transmission, and cell proliferation. Targeting the autoimmune response to gangliosides may represent an underexploited opportunity to examine the increased incidence of neurological complications related to ZIKV infection.

• 出版日期2016-3-21