Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents

作者：曾汉林; 林辰初; 卢俊彦; 谢作权; 孙文怡; 丁健; 袁胜涛; 耿美玉; 黄敏; ChengLuo

来源：中国工程院医药卫生学部、中国抗癌协会抗癌药物专业委员会、中国药理学会肿瘤药理专业委员会, 中国辽宁沈阳.

• SOD
• Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents
• ROS

Purpose Cancer cells are characterized by a high dependency on antioxidant enzymes to cope with the elevated rates of reactive oxygen species(ROS).Impairing antioxidant capacity in cancer cells disturbs the ROS homeostasis and exposes cancer cells to massive oxidative stress that leads to cell death...

• 出版日期2015
• 单位中国药科大学; 新药研究国家重点实验室; 中科院上海药物研究所