Alterations of IGF-1, complement C3 and superoxide dismutase in patients with moderate-to-severe obstructive sleep apnea hypopnea syndrome

作者：Wang, Xiao; Wang, Yufeng; Cai, Zechuan; Lu, Xiaoxia; Li, Zhenxing; Chen, Yun; Zu, Guoliang; Li, Taoping^*

来源：Biomarkers in Medicine, 2018, 12(3): 217-228.

DOI：10.2217/bmm-2017-0099

• continuous positive airway pressure
• immunity
• inflammation
• metabolism
• obstructive sleep apnea hypopnea syndrome

Aim: To evaluate various biomarkers of metabolism, immunity and inflammation in obstructive sleep apnea hypopnea syndrome (OSAHS). Materials & methods: After overnight polysomnography, blood was collected from 292 OSAHS patients or healthy volunteers. Serum content of inflammatory, immune, metabolic biomarkers were investigated. In addition, the effects of 1-month continuous positive airway pressure (CPAP) were studied in moderate/severe OSAHS. Results: C3, serum total complement activity, superoxide dismutase, uric acid were significantly higher in moderate/severe OSAHS than that in no/mild OSAHS. In contrast, IGF-1 in moderate/severe OSAHS was lower than it in no/mild OSAHS, which was negative correlated with apnea-hypopnea index. Moreover, CPAP significantly decreased C3, meanwhile elevated IGF-1. Conclusion: C3, serum total complement activity and superoxide dismutase were higher in moderate/severe OSAHS, while IGF-1 decreased. Elevated C3 and reduced IGF-1 in moderate/severe OSAHSmay be reversed by CPAP.

• 出版日期2018-3
• 单位南方医科大学