Automated glycan assembly of branched beta-(1,3)-glucans to identify antibody epitopes

作者:Weishaupt M W; Hahm H S; Geissner A; Seeberger P H*
来源:Chemical communications, 2017, 53(25): 3591-3594.
DOI:10.1039/c7cc00520b

摘要

beta-(1,3)-Glucans exhibit immunomodulatory and anti-tumor effects. Since the isolation of pure beta-(1,3)-glucan oligosaccharides from natural sources is complicated, especially when certain branching patterns are desired, chemical synthesis is frequently the only means of accessing these molecules. We report the iterative automated glycan assembly (AGA) of conjugation-ready linear and branched beta-(1,3)-glucan oligosaccharides.

  • 出版日期2017-3-28