Multifunctional Core@Shell Magnetic Nanoprobes for Enhancing Targeted Magnetic Resonance Imaging and Fluorescent Labeling in Vitro and in Vivo

作者：Zhang, Qian; Yin, Ting; Gao, Guo^*; Shapter, Joseph G.; Lai, Weien; Huang, Peng; Qi, Wen; Song, Jie; Cui, Daxiang^*

来源：ACS Applied Materials & Interfaces, 2017, 9(21): 17777-17785.

DOI：10.1021/acsami.7b04288

• core@shell
• magnetic nanoprobes
• MRI
• fluorescent labeling
• biodistribution

Core@shell,magnetic nanoprticles (core@shell MNPs) are attracting widespread attention due to their enhancement properties for potential applications in hyperthermia treatment, magnetic resonance imaging (MRI), diagnostics, and so forth. Herein,we developed a facile thertrial decomposition method for controllable synthesis of a superparamagnetic, monodispersed core@shell structure (Co@Mn = CoFe2O4.@MnFe2O4) with uniform size distribution (sigma < 5%, d(c) 15 nm). The CoFe2O4 core could enhance. magnetic anisotropy, and the MnFe2O4 shell could improve the magnetization value. The CO@Mn MNPs were transferred into aqueous solution with an amphiphilic polymer (labeled 2% TAMRA) and fiinctionolized with PEG(2k), and target molecules (folic acid, FA) to fabricate multifunctional PMA(TAMRA)-Co@Mn-PEG(2k)-FA nanoprobes. The obtained PMA(TAMRA)-Co@Mn-PEG(2k)-FA nanoprobes" exhibit good biocompatibility,, high T-2 relaxation values, and long-term fluorescence stability,(at least 6 months). Our results 'demonstrate that the synthesized PMA(TAMRA)Co@Mn-PEG(2k)-FA nanoprobes can effectively enhance the targeted MRI and fluorescent labeling in vitro and in vivo. The research outcomes will contribute to the rational design of new nanoprobes and ptovide a promising pathway, to promote core@shell nanoprobes for further clinical contrast MRI and photodynamic therapy in the near future.

• 出版日期2017-5-31
• 单位合肥工业大学; 上海交通大学