A role for chromatin topology in imprinted domain regulation

作者：MacDonald William A; Sachani Saqib S; White Carlee R; Mann Mellissa R W^*

来源：Biochemistry and Cell Biology, 2016, 94(1): 43-55.

DOI：10.1139/bcb-2015-0032

• chromatin topology
• genomic imprinting
• long noncoding RNA
• nuclear architecture
• X chromosome inactivation

Recently, many advancements in genome-wide chromatin topology and nuclear architecture have unveiled the complex and hidden world of the nucleus, where chromatin is organized into discrete neighbourhoods with coordinated gene expression. This includes the active and inactive X chromosomes. Using X chromosome inactivation as a working model, we utilized publicly available datasets together with a literature review to gain insight into topologically associated domains, lamin-associated domains, nucleolar-associating domains, scaffold/matrix attachment regions, and nucleoporin-associated chromatin and their role in regulating monoallelic expression. Furthermore, we comprehensively review for the first time the role of chromatin topology and nuclear architecture in the regulation of genomic imprinting. We propose that chromatin topology and nuclear architecture are important regulatory mechanisms for directing gene expression within imprinted domains. Furthermore, we predict that dynamic changes in chromatin topology and nuclear architecture play roles in tissue-specific imprint domain regulation during early development and differentiation.

• 出版日期2016-2