Meltable magnetic biocomposites for controlled release

作者：Mueller R^*; Zhou M; Dellith A; Liebert T; Heinze T

来源：Journal of Magnetism and Magnetic Materials, 2017, 431: 289-293.

DOI：10.1016/j.jmmm.2016.09.031

• Magnetic particles
• Composite material
• Controlled release

New biocompatible composites with adjustable melting point in the range of 30-140 degrees C, consisting of magnetite nanoparticles embedded into a matrix of meltable dextran fatty acid ester are presented which can be softened under an induced alternating magnetic field (AMF). The chosen thermoplastic magnetic composites have a melting range close to human body temperature and can be easily shaped into disk or coating film under melting. The composite disks were loaded with green fluorescent protein (GFP) as a model protein. Controlled release of the protein was realized with high frequent alternating magnetic field of 20 kA/m at 400 kHz. These results showed that under an AMF the release of GFP from magnetic composite was accelerated compared to the control sample without exposure to AMF. Furthermore a texturing of particles in the polymer matrix by a static magnetic field was investigated.

• 出版日期2017-6-1