Phenolic bisabolanes from the sponge-derived fungus Aspergillus sp.

作者：Liu, Shuai; Dai, Haofu; Konuklugil, Belma; Orfali, Raha S.; Lin, Wenhan; Kalscheuer, Rainer; Liu, Zhen^*; Proksch, Peter^*

来源：Phytochemistry Letters, 2016, 18: 187-191.

DOI：10.1016/j.phytol.2016.10.015

• Sponge-derived fungus
• Aspergillus sp.
• Phenolic bisabolanes
• Antibacterial
• Co-cultivation

Two new phenolic bisabolane sesquiterpenes, asperchondols A (1) and B (2), together with seven known analogues (3-9) and four known diphenyl ethers (10-13) were obtained from Aspergillus sp., that had been isolated from the marine sponge Chondrilla nucula. Their structures were elucidated through NMR and MS analysis, and by comparison with literature data. All isolated compounds were evaluated for their antibacterial activity against eight human pathogenic bacteria. Co-cultivation experiment of Aspergillus sp. with Bacillus subtilis was also conducted.

• 出版日期2016-12
• 单位北京大学; 中国热带农业科学院椰子研究所; 天然药物与仿生药物国家重点实验室; 中国热带农业科学院