Alliin attenuates 1, 3-dichloro-2-propanol-induced lipogenesis in HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway

作者：Lu, Jing; Cheng, Bijun; Meng, Zhuoqun; Fang, Baochen; Li, Tianjiao; Sun, Maocheng; Liu, Meitong; Guan, Shuang^*

来源：Life Sciences, 2018, 195: 19-24.

DOI：10.1016/j.lfs.2017.12.040

• SACS
• 1,3-DCP
• Lipogenesis
• AMPK
• SREBP
• HMGCR

Accumulating evidence reveals the association of 1, 3-dichloro-2-propanol (1, 3-DCP) exposure and lipogenesis. Alliin, the most abundant sulphur compound in garlic, has been demonstrated to exhibit hypoglycemic, antioxidant and anti-inflammatory activities. Here, we showed that alliin attenuated lipogenesis induced by 1,3-DCP and that the reduction was due to activation of the AMPK pathway. HepG2 cells exposed to 1,3-DCP exhibited significant increase of triglyceride(TG) and total cholesterol(TC), and alliin reduced the accumulation. Most importantly, alliin could up-regulate the phosphorylation of AMPK and down-regulate protein and gene expressions of SREBP-1; FAS; SREBP-2; HMGCR in 1,3-DCP-induced HepG2 cells. The results demonstrated that alliin was effective on attenuating 1,3-DCP-induced lipogenesis via activation of the AMPK-SREBPs signaling pathway in HepG2 cells.

• 出版日期2018-2-15
• 单位吉林农业科技学院; 吉林大学