Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention

作者：Matsuoka Yoichiro^*; Hamaguchi Tetsuya; Fukamachi Katsumi; Yoshida Midori; Watanabe Gen; Taya Kazuyoshi; Tsuda Hiroyuki; Tsubura Airo

来源：Medical Molecular Morphology, 2007, 40(4): 185-190.

DOI：10.1007/s00795-007-0369-4

• mammary carcinoma
• preneoplasia
• prevention
• ras
• transgenic rat

A rat strain carrying the human c-Ha-ras proto-oncogene is highly susceptible to chemically induced mammary carcinogenesis. All the transgenic rats develop preneoplastic mammary lesions within 20 days of an injection of N-methyl-N-nitrosourea, and mammary carcinomas appear within 8 weeks of treatment with a variety of chemical carcinogens. In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention.

• 出版日期2007-12