Hybrid Capture 2 High-Risk Human Papillomavirus Test Should %26quot;Grey Zone%26quot; Results Justify Repeating the Test?

作者：Ramirez Hidalgo Angels; Musset Biarnes Merce; Vilamala Muns Maria; Laso Perez Elisa; Serrano Munne Laia; Alameda Quitllet Francesc^*

来源：Analytical and Quantitative Cytology and Histology, 2013, 35(3): 152-156.

• cervical smears
• cytology
• HPV DNA tests
• human papillomavirus

OBJECTIVE: To determine the clinical importance of repeating the Hybrid Capture 2 (HC2) high-risk human papillomavirus (HPV) test when the result obtained falls between 2.7 and 0.8 pg/mL, the so-called %26quot;grey zone.%26quot; %26lt;br%26gt;STUDY DESIGN: Repeat testing was performed on 139 thin-layer liquid-based cytology cervicovaginal samples that were found to fall in the grey zone. The samples represented a variety of cytological diagnoses. The results of both HPV HC2 tests were analyzed related to the cytological diagnosis of both the previous and the follow-up cytological samples. %26lt;br%26gt;RESULTS: The change of the HPV HC2 result from positive (2.7-1 pg/mL) to negative (%26lt;1 pg/mL) when repeating the test is not related with the diagnosis obtained in the cytological follow-up of the patient. %26lt;br%26gt;CONCLUSION: The HC2 test should not be repeated when the result falls between 2.7 and 0.8 pg/mL. In these cases the result of the cytology is more relevant and should be used in the clinical assessment of the patient.

• 出版日期2013-6