Hybrid imaging of the bowel using PET/MR enterography: Feasibility and first results

作者：Beiderwellen Karsten^*; Kinner Sonja; Gomez Benedikt; Lenga Lukas; Bellendorf Alexander; Heusch Philipp; Umutlu Lale; Langhorst Jost; Ruenzi Michael; Gerken Guido; Bockisch Andreas; Lauenstein Thomas C

来源：European Journal of Radiology, 2016, 85(2): 414-421.

DOI：10.1016/j.ejrad.2015.12.008

• PET/MR
• Small bowel
• Large bowel

Purpose: To implement a protocol for PET/MR enterography for a multimodal assessment of intestinal pathologies.
Materials and Methods: 19 patients with bowel malignancies, Crohn's disease or fever of unknown origin (male: n= 14, female: n= 5, age: 57 + 13 years) underwent PET/MR enterography with either [18F]FDG (n=10) or [68Ga [-DOTATOC (n= 9) using an integrated scanner. For small bowel distension a contrast solution (1500 cm3 of mannitol and locust bean gum) was ingested. The following sequences were acquired: (a) coronal TrueFISP; (b) coronal T2w HASTE; (c) coronal dynamic Tlw VIBE; (d) axial and coronal Tlw FLASH post gadolinium. All datasets were reviewed by two readers with regard to co-registration of anatomical structures based on a 3-point ordinal scale as well as overall image quality using a 4-point ordinal scale. Furthermore, visualization of intestinal and extra-intestinal pathologies was assessed.
Results: PET/MR enterography was well tolerated by all patients. High overall MR image quality was achieved (mean score: 3.2 + 0.6) with good co-registration of PET and MRI (mean scores: 2.6 to 3.0). PET/MR enterography allowed for an excellent visualization of both intestinal as well as extra-intestinal pathologies.
Conclusion: PET/MR enterography is technically feasible and offers good co-registration of bowel structures. This novel method enables a multimodal assessment of bowel lesions in malignant and inflammatory disease.

• 出版日期2016-2