Multi-scale heat and mass transfer modelling of cell and tissue cryopreservation

作者:Xu, Feng; Moon, Sangjun; Zhang, Xiaohui; Shao, Lei; Song, Young Seok*; Demirci, Utkan
来源:Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences, 2010, 368(1912): 561-583.
DOI:10.1098/rsta.2009.0248

摘要

Cells and tissues undergo complex physical processes during cryopreservation. Understanding the underlying physical phenomena is critical to improve current cryopreservation methods and to develop new techniques. Here, we describe multi-scale approaches for modelling cell and tissue cryopreservation including heat transfer at macroscale level, crystallization, cell volume change and mass transport across cell membranes at microscale level. These multi-scale approaches allow us to study cell and tissue cryopreservation.

  • 出版日期2010-2-13