An MRI study of amygdala in schizophrenia and psychotic bipolar disorder

作者：Mahon Pamela Belmonte^*; Eldridge Haley; Crocker Britni; Notes Lisa; Gindes Holly; Postell Elizabeth; King Stacey; Potash James B; Ratnanather J Tilak; Barta Patrick E

来源：Schizophrenia Research, 2012, 138(2-3): 188-191.

DOI：10.1016/j.schres.2012.04.005

• Amygdala
• MRI
• Psychotic bipolar disorder
• Schizophrenia

Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had smaller amygdala compared with patients with psychotic bipolar disorder (p=0.014). These results suggest that change in volume of amygdala may represent a morphologic feature distinguishing psychotic bipolar disorder from schizophrenia.

• 出版日期2012-7