1,5-Hydride transfer protocol for the synthesis of beta-branched polyketide structural units

作者：Stefan Eric; Taylor Richard E^*

来源：Tetrahedron Letters, 2015, 56(23): 3416-3419.

DOI：10.1016/j.tetlet.2015.01.020

• Hydride transfer
• Stereochemistry
• Natural product

A novel method to induce 1,5-hydride transfer for the production of methyl substituted polyketide structural units was developed. A new avenue to the formation of a tertiary stereocenter was accomplished through the activation of benzyl protected homoallylic substrates with a variety of electrophilic activating conditions.

• 出版日期2015-6-3