Does Dose Matter? Effect of Two Different Neoadjuvant Protocols in Advanced NSCLC

作者：Steger Volker; Veit Stefanie; Walker Tobias^*; Friedel Godehard; Lehrach Karoline; Mustafi Migdat; Walles Thorsten

来源：Thoracic and Cardiovascular Surgeon, 2013, 61(2): 109-115.

DOI：10.1055/s-0032-1311529

• airway (includes related subject matter)
• chemotherapy
• lung cancer treatment (surgery medical)

Background For stage III, NSCLC neoadjuvant protocols have been intensified up to full dose protocols but up till now the effect of more intensive protocols in a trimodal setting could not be compared directly because of different selection criteria or experience of involved facilities in different studies or multicenter studies. We analyzed our experience with two different neoadjuvant protocols, consistent selection criteria, and surgical teams over 17-year time period. %26lt;br%26gt;Method Single-center retrospective study in 159 patients concerning survival, recurrence, and downstaging effect. %26lt;br%26gt;Results Overall median survival was 32 months, with 26 months for protocol 1, and 35 months for protocol 2, respectively. Hospital mortality was 5%. Log-rank test showed significant difference between the protocols for UICC-downstaging-effect, ypT-stage, ypN-stage, and ypUICC-stage, respectively, but only ypN-stage and ypUICC-stage were significant risk factors for survival using Cox regression. %26lt;br%26gt;Conclusion The median survival benefit of 9 months is evident but (probably still) not significant. The more aggressive protocol 2 shows a significant better downstaging effect concerning N- and UICC-stage if R0-resection can be achieved. Insofar dose does matter!

• 出版日期2013-3