Associations between cytotoxic T lymphocyte-associated antigen-4 polymorphisms and serum tumor necrosis factor-alpha and interferon-gamma levels in patients with chronic hepatitis B virus infection

作者：Han Qunying; Duan Shaoqiong; Zhang Guoyu; Li Zhu; Li Na; Zhu Qianqian; Lv Yi; Chen Jinghong; Liu Zhengwen^*

来源：Inflammation Research, 2011, 60(11): 1071-1078.

DOI：10.1007/s00011-011-0368-8

• Chronic HBV infection
• Cytotoxic T lymphocyte-associated antigen 4
• Genetic polymorphism
• Tumor necrosis factor-alpha
• Interferon-gamma

Background Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) polymorphism, which may affect host immune response including cytokines production, is thought to be associated with hepatitis B virus (HBV) infection. This study investigated the associations between CTLA4 polymorphism and serum tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma levels in patients with chronic HBV infection.
Methods CTLA4 promoter -318C/T and exon 1 +49A/G polymorphisms and serum TNF-alpha and IFN-gamma levels were determined in 172 patients with chronic HBV infection and 145 healthy controls.
Results The genotype of CTLA4 -318C/T polymorphism had no association to TNF-alpha and IFN-gamma levels. Serum levels of TNF-alpha and IFN-gamma in chronic HBV patients with +49GG genotype were lower than those with +49AG genotype (p = 0.030 and p = 0.042, respectively), and haplotypes -318C + 49A and -318C + 49G seemed to have no significant effects on TNF-alpha and IFN-gamma levels.
Conclusions CTLA4 +49GG genotype was associated to lower TNF-alpha and IFN-gamma levels in patients with chronic HBV infection but this association was diminished by haplotype formation with -318C/T alleles, indicating that the influence of CTLA4 -318C/T and +49A/G polymorphisms on the susceptibility and disease progress of chronic HBV infection may not be effectuated by affecting TNF-alpha and IFN-gamma secretion.

• 出版日期2011-11
• 单位西安交通大学