A One-Pot Parallel Reductive Amination of Aldehydes with Heteroaromatic Amines

作者：Bogolubsky Andrey V; Moroz Yurii S^*; Mykhailiuk Pavel K; Panov Dmitriy M; Pipko Sergey E; Konovets Anzhelika I; Tolmachev Andrey

来源：ACS Combinatorial Science, 2014, 16(8): 375-380.

DOI：10.1021/co5000568

• heteroaromatic amines
• reductive amination
• trimethylsilyl acetate
• one-pot approach
• parallel synthesis

A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)(3) (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.

• 出版日期2014-8