A comparative analysis of the cell biology of senescence and aging

作者：Hwang Eun Seong^*; Yoon Gyesoon; Kang Hyun Tae

来源：Cellular and Molecular Life Sciences, 2009, 66(15): 2503-2524.

DOI：10.1007/s00018-009-0034-2

• Replicative senescence
• Postmitotic cell
• Aging
• Fibroblast
• Lysosomes
• Mitochondria
• Senescence-associated heterochromatin foci (SAHF)
• Telomere dysfunction-induced focus (TIF)

Various intracellular organelles, such as lysosomes, mitochondria, nuclei, and cytoskeletons, change during replicative senescence, but the utility of these changes as general markers of senescence and their significance with respect to functional alterations have not been comprehensively reviewed. Furthermore, the relevance of these alterations to cellular and functional changes in aging animals is poorly understood. In this paper, we review the studies that report these senescence-associated changes in various aging cells and their underlying mechanisms. Changes associated with lysosomes and mitochondria are found not only in cells undergoing replicative or induced senescence but also in postmitotic cells isolated from aged organisms. In contrast, other changes occur mainly in cells undergoing in vitro senescence. Comparison of age-related changes and their underlying mechanisms in in vitro senescent cells and aged postmitotic cells would reveal the relevance of replicative senescence to the physiological processes occurring in postmitotic cells as individuals age.

• 出版日期2009-8