Novel Chiral Ionic Liquid (CIL) Assisted Selectivity Enhancement to (L)-Proline Catalyzed Asymmetric Aldol Reactions

Zhang, Long; Zhang, Haibo<sup>*</sup>; Luo, Huadong; Zhou, Xiaohai; Cheng, Gongzhen

doi:10.1590/S0103-50532011000900016

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Novel Chiral Ionic Liquid (CIL) Assisted Selectivity Enhancement to (L)-Proline Catalyzed Asymmetric Aldol Reactions

作者：Zhang, Long; Zhang, Haibo^*; Luo, Huadong; Zhou, Xiaohai; Cheng, Gongzhen

来源：Journal of the Brazilian Chemical Society, 2011, 22(9): 1736-1741.

DOI：10.1590/S0103-50532011000900016

摘要

A significant improvement of the chemical yields (up to 88%), stereoselectivity (> 99:1) and enantiomeric excesses (up to 98%) of (L)-proline catalyzed direct asymmetric aldol reaction was found when proline based chiral ionic liquids (CILs) were added as additives. Different ratios of DMSO/H2O as solvent and chiral ionic liquids (CILs) with chiral cations of different chain length were investigated.