A Dysprosium Nanowire Modified Carbon Paste Electrode for Determination of Nanomplar Level of Diphenhydramin by Continuous Square Wave Voltammetry in Flow Injection System

作者：Daneshgar Parandis^*; Norouzi Parviz; Ganjali Mohammad Reza; Dousty Faeze

来源：International Journal of Electrochemical Science, 2009, 4(3): 444-457.

• Fast Fourier Transformation
• Square wave voltammetry
• Carbon paste electrode
• Dysprosium nanowire
• Diphenhydramin
• Oxidation-reduction

A new detection technique called the fast Fourier transform square-wave voltammetry (FFT SWV) is based on measurements of electrode admittance as a function of potential. The response of the detector (microelectrode) is fast, which makes the method suitable for most applications involving flowing electrolytes. The carbon paste electrode was modified by nanostructures to improve better sensivity. The redox property of Diphenhydramin was used for determination of it in human serum and urine samples. Synthesized dysprosium nanowires make more effective surface like nanotubes [1-4] so they are good candidates for using as a modifier for electrochemical reactions. The drug presented one irreversible oxidation peaks at 1080mV vs. Ag/AgCl by modified Nanowire carbon paste electrode which produced high current and reduced the oxidation potential about 300mV. Furthermore, signal-to-noise ratio has significantly increased by application of discrete fast Fourier Transform (FFT) method, background subtraction and two-dimensional integration of the electrode response over a selected potential range and time To obtain the much sensivity the effective parameters such as frequency, amplitude and pH was optimized. As a result, LOD of 4.0x10(-11)mol l(-1) and an LOQ of 8.0x 10(-11) mol l(-1) were found for determination for Diphenhydramin. A good recovery was obtained for assay spiked urine samples and a good quantification of Diphenhydramin was achieved in a commercial formulation.

• 出版日期2009-3