Computer modeling of triterpene glycosides interaction with natural polymer chitosan

作者:Mironenko N V*; Smuseva S O; Brezhneva T A; Selemenev V F; Nechaeva L S
来源:Russian Journal of General Chemistry, 2016, 86(11): 2526-2533.
DOI:10.1134/S1070363216110207

摘要

By means of computer modeling, the main regularities of the interaction of triterpene saponins with chitosan are revealed. It is shown that the sorption of glycosides changes the ordered configuration of chitosan, and the complex of chitosan with saponin, the derivative of quillaic acid, is more stable than the complex with the derivative of oleanolic acid. The formation of complexes occurs due to electrostatic, hydrophobic interactions, and hydrogen bonds, whose strength is determined by the nature, geometry, and specific structure of terpenes of the beta-amyrin series.

  • 出版日期2016-11