Association of serum lipid indices and statin consumption with periodontal status

作者：Sayar F^*; Fallah S; Akhondi N; Jamshidi S

来源：Oral Diseases, 2016, 22(8): 775-780.

DOI：10.1111/odi.12545

• hyperlipidemia
• periodontitis
• simvastatin
• cholesterol

ObjectivesPeriodontal and cardiovascular diseases share some common underlying mechanisms. Hyperlipidemia is a major risk factor for cardiovascular diseases. This study sought to assess the association of hyperlipidemia and statin consumption with periodontal status.
Materials and MethodsThis cross-sectional study was conducted on 150 participants including 50 individuals with normal lipid profile (group C), 50 hyperlipidemic patients without drug therapy (group N), and 50 hyperlipidemic patients on drug therapy for a minimum of 3months (group S). Periodontal parameters including plaque index (PI), clinical attachment level (CAL), bleeding on probing (BOP), and pocket depth (PD) were measured for all teeth except for the third molars. Serum levels of total cholesterol (TC), HDL, LDL, and triglycerides (TGs) were measured.
ResultsThe mean values of CAL and PD were significantly higher in the two hyperlipidemic groups compared with the C group (P<0.005). Also, CAL and PD had significant associations with serum levels of TGs, LDL, and TC (P<0.0001); PI in the group S was significantly lower than that in the other groups (P<0.005).
ConclusionsHyperlipidemic patients showed higher values of periodontal parameters compared with the statin-treated and control groups. Lower PI in the group S may indicate the anti-inflammatory effect of statin.

• 出版日期2016-11