Negishi coupling of 2-pyridylzinc bromide-paradigm shift in cross-coupling chemistry?

作者：Coleridge Brian M; Bello Charles S; Ellenberger David H; Leitner Andreas^*

来源：Tetrahedron Letters, 2010, 51(2): 357-359.

DOI：10.1016/j.tetlet.2009.11.036

The efficient cross-coupling of 2-pyridylzinc bromide with functionalized aryl halides has been accomplished by a simple and highly efficient protocol. To the best of our knowledge, we report the first shelf life study of 2-pyridylzinc bromide which confirms the excellent stability of this Compound and underlines the synthetic value of organozinc reagents in the cross-coupling reactions of sensitive heterocyclic nucleophiles on academic and commercial scale.

• 出版日期2010-1-13